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Insmed's Phase 2 trial investigating the efficacy
of Arikayce in NTM patients missed its primary endpoint but achieved statistical significance on a meaningful secondary endpoint which
is the current primary endpoint in the Phase 3 trial.
As we addressed in our previous article, clinical development comes with many forks
in the road and Insmed's Phase 2 readout provided hope
for NTM patients that Arikayce could work if an appropriate Phase 3 trial was structured to
indicate efficacy over SoC.Understanding the potential readout of a trial is seminal to
biotech investing success. A component of this comprehension is knowing the
detailed evolution of Phase 2 to Phase 3 trial design and what the
changes between the trials could mean for the final data readout.Figure 1 details
the Phase 2 baseline demographics and characteristics
table published in the American Journal of Respiratory
and Critical Care Medicine.

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How does uSwitch make money? The majority of uSwitch revenue is derived
from commissions paid by participating service providers.
A commission is collected by uSwitch when a consumer service is switched to a new provider.
The company has contractual arrangements with the
leading service providers in each home service category.

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We also added more customers in the fourth quarter than any other
quarter of Pure's history and we were very pleased with the mix across
our target segments.Purchase rates remain steady
with approximately 70% of our business coming from existing customers.
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